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miconazole (Monistat, Lotrimin AF)

Tradenames: Monistat, Lotrimin. Indications: - oropharyngeal candidiasis - treatment of vulvovaginal candidiasis (Monistat) - treatment of athlete's foot (Lotrimin AF powder, spray) Dosage: Tinea & Candida: 1) 2% cream/powder/spray BID 2) vaginal candidiasis: 1 200 mg vaginal suppository QHS for 3 days Adverse effects: 1) common (> 10%) - fever/chills, rash, itching, anorexia, diarrhea, nausea/vomiting, pain at site of injection 2) less common (1-10%) - anemia, thrombocytopenia 3) uncommon (< 1%) - flushing of face & skin, drowsiness Drug interactions: -> rarely may significantly inhibit warfarin metabolism, increasing its anticoagulant effect Mechanism of action: -> fungistatic [4]

Interactions

drug interactions

Related

candidiasis

General

antifungal agent imidazole; glyoxaline; 1,3-diazole; iminazole

Properties

MISC-INFO: pregnancy-category + safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Prescriber's Letter 8(4):23 2001
  4. Prescriber's Letter 9(2):11 2002
  5. Department of Veterans Affairs, VA National Formulary

Component-of

chlorhexidine/miconazole chlorhexidine/miconazole/nitrate cortisol/gentamicin/miconazole cortisol/miconazole/nitrate dimethicone/miconazole/nitrate/zinc oxide dimethicone/miconazole/zinc oxide miconazole/nitrate miconazole/nitrate/polymixin b/prednisolone miconazole/nitrate/white petrolatum/zinc oxide miconazole/salicylic acid miconazole/triclosan miconazole/white petrolatum/zinc oxide (Vusion)