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melanoma inhibitory activity protein 3 (protein TANGO, C219-reactive peptide, D320, MIA3, KIAA0268, UNQ6077/PRO20088)
Compartment: membrane
Structure:
- belongs to the MIA/OTOR family
- contains 1 SH3 domain
Alternative splicing: named isoforms=4
Expression:
- widely expressed, except in bone marrow & peripheral blood mononuclear cells
Pathology: down-regulated in melanoma tissue
Related
melanoma
melanoma-derived growth regulatory protein; melanoma inhibitory activity protein (MIA)
General
phosphoprotein
transmembrane 2 protein
Properties
SIZE: MW = 214 kD
entity length = 1907 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-1144}
MOTIF: signal sequence {1-22}
src homology 3 [SH3] domain
SITE: 45-107
coiled coil {471-531}
transmembrane domain {1145-1165}
exoplasmic loop {1166-1176}
transmembrane domain {1177-1197}
cytoplasmic domain {1198-1907}
MOTIF: coiled coil {1214-1396}
coiled coil {1487-1639}
proline-rich region
SITE: 1640-1890
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1727}
Ser phosphorylation site {S1739}
Ser phosphorylation site {S1740}
Ser phosphorylation site {S1892}
Database Correlations
UniProt Q5JRA6
Pfam PF07653