MHC class II antigen (HLA-DR, HLA-DP, HLA-DQ)

Classification: includes HLA-DR, DQ & DP molecules Function: - recognized in association with antigen by CD4/TCR Expression: - present on monocytes, macrophages & dendritic cells - can be induced in endothelial cells, renal tubular epithelial cells & fibroblasts by interferon

General

glycoprotein major histocompatibility complex [MHC] antigen multisubunit protein

Properties

COMPARTMENT: plasma membrane SUBUNITS: MHC class II alpha chain MOTIF: glycosylation site immunoglobulin superfamily domain transmembrane domain MHC class II beta chain MOTIF: glycosylation site immunoglobulin superfamily domain transmembrane domain

References

Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 170

Components

MHC class II alpha chain MHC class II beta chain