MHC class I antigen

Classification: includes HLA-A, B & C molecules Function: - recognized in association with antigen by CD8/TCR Expression: - present on virtually all nucleated cells & platelets

Specific

HLA class I histocompatibility antigen protein P5 (HLA complex protein P5, protein P5-1) (HCP5) HLA-A antigen HLA-B antigen HLA-C antigen

General

glycoprotein major histocompatibility complex [MHC] antigen multisubunit protein

Properties

COMPARTMENT: plasma membrane SUBUNITS: MHC class I alpha chain MOTIF: glycosylation site immunoglobulin superfamily domain transmembrane domain beta-2-microglobulin MOTIF: signal sequence {1-20} immunoglobulin superfamily domain {25-113} MOTIF: cysteine residue {C45} MODIFICATION: cysteine residue {C100} cysteine residue {C100} MODIFICATION: cysteine residue {C45}

References

Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 170

Components

beta-2-microglobulin (B2M) MHC class I heavy chain or MHC class I alpha MHC class I heavy chain or MHC class I alpha