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microfibrillar-associated protein 2; MFAP-2; microfibril-associated glycoprotein 1; MAGP; MAGP-1 (MFAP2, MAGP1)
Function:
- component of the elastin-associated microfibrils
- forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils
- may form transglutaminase cross-links
- forms a ternary complex with BGN & ELN (putative)
Structure:
- O-glycosylated
- belongs to the MFAP family
- contains 1 SXC (ShKT) domain
Compartment:
- secreted, extracellular space, extracellular matrix
Alternative splicing: named isoforms=3; A, A', B
General
microfibrillar associated protein
Properties
SIZE: entity length = 183 aa
MW = 21 kD
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-17}
glutamate-rich region {59-73}
MOTIF: glutamate residue (SEVERAL)
SXC {153-183}
MOTIF: cysteine residue {C153}
MODIFICATION: cysteine residue {C183}
cysteine residue {C160}
MODIFICATION: cysteine residue {C176}
cysteine residue {C169}
MODIFICATION: cysteine residue {C180}
cysteine residue {C176}
MODIFICATION: cysteine residue {C160}
cysteine residue {C180}
MODIFICATION: cysteine residue {C169}
cysteine residue {C183}
MODIFICATION: cysteine residue {C153}
Database Correlations
OMIM 156790
UniProt P55001
PFAM correlations
Entrez Gene 4237
Kegg hsa:4237
References
- UniProt :accession P55001
- OMIM :accession 156790