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mezlocillin (Mezlin, Baypen)
Tradename: Mezlin. 4th generation penicillin.
Indications:
- bacterial infections due to susceptible organisms
- intra-abdominal infections
- cholangitis [3]
- urogenital infection
- gonorrhea
- anaerobic infections
- brain abscess
- skin or soft tissue infection
- infectious arthritis, osteomyeltitis [3]
Dosage: 3-4 g IV/IM every 4-6 hours.
Dosage adjustment in renal failure:
creatinine clearance dosage
> 50-90 mL/min every 4-6 hours
10-50 mL/min every 6-8 hours
< 10 mL/min* every 8 hours
* no additional dosing for hemodialysis
Pharmacokinetics:
- elimination 1/2life 1.1 hours (2.6-5.4 hours ESRD)
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Enterococcus faecalis (+/-)
- Enterococcus faecium (+/-)
- Listeria monocytogenes
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Haemophilus influenzae (+/-)
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Serratia species
- Salmonella species
- Shigella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Morganella species
- Citrobacter species
- Aeromonas species
- Pseudomonas aeruginosa
- Xanthomonas maltophilia (+/-)
- Yersinia enterocolitica
- Pasteurella multocida
Anaerobes
- Bacteroides fragilis
- Bacteroides melaninogenicus
- Clostridium difficile
- Clostridium species
- Peptostreptococcus species
Interactions
drug interactions
General
4th generation penicillin (extended-spectrum)
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Deprecated Reference