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mevastatin
Mevastatin requires lactone hydrolysis for activation.
Adverse effects:
1) gastrointestinal
- hepatitis
- increased serum transaminases
2) musculoskeletal
- myopathy
- myalgias
- increased serum creatine kinase
- rhabdomyolysis
- renal failure
3) potentially teratogenic
Mechanism of action:
1) inhibition of HMG CoA reductase
2) maximal effect (80 mg/day)
a) total cholesterol: decrease of 20%
b) LDL cholesterol: decrease of 32%
c) HDL cholesterol: increase of 4%
d) triglycerides: no change
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with HMG CoA reductase inhibitors (statins)
General
lipophilic statin
Properties
INHIBITS: HMG CoA reductase
MISC-INFO: elimination route LIVER
Database Correlations
PUBCHEM correlations
References
Goodman and Gilman's The Pharmacological Basis of
Therapeutics, 8th ed. Gilman et al, eds.
Permagon Press/McGraw Hill, 1990. pg 882