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mevalonate kinase (MVK)
Function:
1) cholesterol biosynthesis
- may be a regulatory site in cholesterol biosynthetic pathway
2) isoprenoid biosynthesis
- isopentenyl-PP biosynthesis via mevalonate pathway
- isopentenyl-PP from R-mevalonate: step 1/3
3) farnesyl-pyrophosphates & geranyl-pyrophosphate are competitive inhibitors
ATP + (R)-mevalonate ADP + (R)-5-phosphomevalonate
Structure:
- homodimer
- belongs to the GHMP kinase family, mevalonate kinase subfamily
Compartment: cytoplasm, peroxisome
Pathology:
- defects associated with
a) mevalonicaciduria
b) hyper IgD syndrome
Interactions
molecular events
Related
cholesterol biosynthesis
mevalonate kinase gene
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 396 aa
MW = 42 kD
COMPARTMENT: peroxisome
cytoplasm
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 138-148
Database Correlations
OMIM correlations
MORBIDMAP 251170
UniProt Q03426
PFAM correlations
Entrez Gene 4598
Kegg hsa/hsa00100
ENZYME 2.7.1.36
References
- Primary Hyperlipoproteinemias, Steiner & Shafrir (eds),
McGraw Hill, NY, 1991, pg 14
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MVK
- UniProt :accession Q03426