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tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase, methyltransferase-like protein 1, METTL1, C12orf1)
Function:
- catalyzes the formation of 7-N-methylguanine at position 46 (m7G46) in tRNA
- forms a complex with WDR4
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + tRNA containing 7-N-methylguanine
Structure:
- belongs to the methyltransferase superfamily, TrmB family
Expression: ubiquitous
Related
WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4)
General
methyltransferase
Properties
SIZE: MW = 31 kD
entity length = 276 aa
MOTIF: active site
Database Correlations
OMIM 604466
UniProt Q9UBP6
Pfam PF02390
ENZYME 2.1.1.33
References
UniProt :accession Q9UBP6