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metipranolol (Optipranolol)

Tradename: Optipranolol. Indications: - increased intraocular pressure - chronic open-angle glaucoma - closed-angle glaucoma - secondary glaucoma Contraindications: Caution: 1) bronchial asthma 2) sinus bradycardia 3) 2nd & 3rd degree AV block 4) heart failure Dosage: 1 drop OU BID. 0.3% (5 mL, 10 mL). Pharmacokinetics: 1) initial reduction of intraocular pressure in 30 minutes 2) maximal reduction of intraocular pressure in 2 hours 3) duration of action: up to 24 hours Adverse effects: 1) common (> 10%) - mild ocular stinging & discomfort (transient, 56%) - eye irritation 2) less common (1-10%) - blurred vision, eyebrow ache 3) uncommon (< 1%) - conjunctivitis, blepharitis, bradycardia, AV block, congestive heart failure (CHF), asthenia, tearing, erythema, itching, keratitis, photophobia, decreased corneal sensitivity, bronchospasm Mechanism of action: 1) non-selective beta blocker 2) reduces aqueous humor production

Interactions

drug interactions drug adverse effects (more general classes)

General

non-specific beta-adrenergic receptor antagonist (non-specific beta-blocker)

Database Correlations

PUBCHEM correlations

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Deprecated Reference