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metastasis suppressor protein 1; missing in metastasis protein; metastasis suppressor YGL-1 (MTSS1, MIM, KIAA0429)
Function:
- may be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton
- binds to actin
- binds to the cytoplasmic domain of receptor-type tyrosine phosphatase delta (PTPRD)
Structure:
- the WH2 motif at the C-terminus binds to actin monomers
- belongs to the MTSS1 family
- contains 1 IMD (IRSp53/MIM homology) domain
- contains 1 WH2 domain
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=3
Expression:
- expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, & peripheral blood
General
phosphoprotein
Properties
SIZE: entity length = 755 aa
MW = 82 kD
COMPARTMENT: cytoplasm
MOTIF: IMD {1-250}
MOTIF: coiled coil {108-155}
serine-rich region {238-359}
MOTIF: serine residue (SEVERAL)
Thr phosphorylation site {T258}
Ser phosphorylation site {S261}
Ser phosphorylation site {S272}
Ser phosphorylation site {S315}
Ser phosphorylation site {S316}
Tyr phosphorylation site {Y526}
Ser phosphorylation site {S569}
Thr phosphorylation site {T603}
proline-rich region
SITE: 608-726
MOTIF: proline residue (SEVERAL)
WH2 {727-744}
Database Correlations
OMIM 608486
UniProt O43312
PFAM correlations
Entrez Gene 9788
Kegg hsa:9788
References
UniProt :accession O43312