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metapneumovirus (MPV)
Etiologic agent of respiratory infections in children.
Epidemiology:
1) 80% of infections occur between February & May [6]
2) high rate of infection in infants 0-5 months of age [6]
3) infective for primates, but not birds [4]
4) 6% of inpatients [8]
5) 7% of outpatients
6) 7% of emergency department patients
8) 1% of asymptomatic controls [8]
Pathology:
1) produces pathology similar to respiratory syncytial virus (RSV)
2) spectrum of disease from rhinitis to severe bronchitis & pneumonia
Genetics:
- related to an avian virus
Clinical manifestations:
1) 12% if children with lower respiratory tract infection
a) bronchiolitis
b) pneumonitis
c) asthma
2) 15% if children with upper respiratory tract infection
3) 1% of asymptomatic children
Laboratory:
1) isolation from nasopharyngeal aspirates
2) metapneumovirus antigen
3) RT-PCR for metapneumovirus RNA
4) metapneumovirus IgG in serum
- nearly 100% of adults have antibody to MPV
5) see ARUP consult [7]
General
virus
Properties
KINGDOM: virus
References
- Journal Watch 21(13):108, 2001
van den Hoogen BG et al
A newly discovered human pneumovirus isolated from young
children with respiratory tract disease.
Nat Med. 2001 Jun;7(6):719-24.
PMID: 11385510
- van den Hoogen BG et al,
Clinical impact and diagnosis of human metapneumovirus
infection.
Pediatr Infect Dis, 23(1 suppl): S25, 2004 (review)
PMID: 14730267
- van den Hoogen et al,
Analysis of the genomic sequence of a human metapneumovirus.
Virology 295:119-32, 2002
PMID: 12033771
- Journal Watch 24(5):42, 2004
Williams JV et al
Human metapneumovirus infection in young children hospitalized
with acute respiratory tract disease: virologic and clinical
features.
N Engl J Med 350:443, 2004
PMID: 14749452
- Caracciolo S et al,
Human metapneumovirus infection in young children hospitalized
with acute respiratory tract disease: Virologic and clinical
features.
Pediatr Infect Dis J 2008, 27:406
PMID: 18382388
- Williams JV et al.
Population-based incidence of human metapneumovirus infection
among hospitalized children.
J Infect Dis 2010 Jun 15; 201:1890.
PMID: 20446850
- ARUP Consult: Metapneumovirus - hMPV
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/browse-all-topics
- Edwards KM et al.
Burden of human metapneumovirus infection in young children.
N Engl J Med 2013 Feb 14; 368:633.
PMID: 23406028
http://www.nejm.org/doi/full/10.1056/NEJMoa1204630