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Metallothionein-1A; MT-1A; Metallothionein-IA; MT-IA (MT1A MT1S)
Structure:
- belongs to the metallothionein superfamily, type 1 family
- metallothioneins have a high content of Cys that bind various heavy metals
- class 1 metallothioneins contain 2 metal-binding domains:
a) 4 divalent ions are chelated within cluster A of the alpha domain & are coordinated via cysteinyl thiolate bridges to 11 Cys ligands
b) cluster B, the corresponding region within the beta domain, can ligate 3 divalent ions to 9 Cys
Expression:
- transcriptionally regulated by both heavy metals & glucocorticoids
General
metallothionein 1
Properties
SIZE: entity length = 61 aa
MW = 6 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Beta {1-29}
cysteine-rich region
MOTIF: cysteine residue (20)
metal ion-binding site
MOTIF: cysteine residue (SEVERAL)
Alpha {30-61}
Database Correlations
OMIM 156350
UniProt P04731
Pfam PF00131
Entrez Gene 4489
References
- UniProt :accession P04731
- Entrez Gene :accession 4489