Contents

Search

metal in urine

Pathology: - metals in urine associated with risk of cardiovascular disease (CVD) dementia & death* Metal RR of CVD RR of death RR of dementia copper 1.42 1.50 1.16 zinc 1.21 1.38 1.35 cobalt 1.24 1.37 1.18 manganese - - 1.00 uranium 1.32 1.32 1.46 tungsten 1.20 1.16 1.15 arsenic - - 1.32 lead - - 0.92 cadmium 1.25 1.68 1.17 * copper, zinc cobalt, manganese, uranium, tungsten, cadmium, arsenic, lead - metals with RR if CVD are associated with coronary artery calcium [2] - higher arsenic in urine is associated with kidney injury [4] * apoE4 allele may increase the relative risk of dementia [3]

Specific

arsenic in urine

General

urine toxicology

References

  1. Lou N These Metals in Urine Predict Heart Disease and Death. Exposure may come from food, water, and air MedPage Today, August 1, 2024 https://www.medpagetoday.com/cardiology/prevention/111319 - Martinez-Morata I, Schilling K, Glabonjat RA et al Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2024. August 1. PMID: 39087344 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069414
  2. McGraw KE, Schilling K, Glabonjat RA et al Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv [Preprint]. 2023 Nov 1:2023.10.31.23297878. PMID: 37961623 PMCID: PMC10635251 Free PMC article. Preprint. - McGraw KE, Schilling K, Glabonjat RA et al Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2024 Sep 12:S0735-1097(24)07961-0 PMID: 39297845 Free article. https://www.jacc.org/doi/10.1016/j.jacc.2024.07.020
  3. George J Cognitive Performance Falls as Metal Exposure Rises. Carrying at least one copy of APOE4 may modify the association. MedPage Today December 3, 2024 https://www.medpagetoday.com/neurology/dementia/113199 - Domingo-Relloso A, McGraw KE, Heckbert SR et al Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis. JAMA Netw Open. 2024;7(12):e2448286. PMID: 39621345 PMCID: PMC11612832 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827187
  4. Hasan NT, Xu X, Han D, Sansom G, Roh T. Association between urinary arsenic levels and kidney damage in US adults: NHANES 2007-2018. J Trace Elem Med Biol. 2024 Dec;86:127559. PMID: 39522452 https://www.sciencedirect.com/science/article/abs/pii/S0946672X24001792