mesolimbic system

Dopaminergic neurons in the ventral tegmental area of the tegmentum mesencephali send fibers to the limbic cortex: 1) entorhinal cortex 2) olfactory tubercle 3) cingulate gyrus 4) frontal cortex. Schizophrenia may be due to an overstimulation of dopamine D2 receptors in the mesolimbic & mesocortical systems. Cocaine & amphetamines produce arousal associated with diminished appetite & need for sleep by stimulating the mesolimbic & mesocortical systems.

Related

dopamine D2 receptor (DRD2) schizophrenia

References

Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999