Search
Merkel cell virus
icosahedral dsDNA virus
lacks a lipoorotein envelope
Size: 5387 base pairs
Epidemiology:
- commonly found in normal human skin
Pathology:
- associated with Merkel cell carcinoma
- integrates at a single site in the human genome at chromosome 3p14 within the PTPRG locus
- expression of a mutated T antigen with oncogenic activity, necessary for survival & proliferation of Merkel cell carcinoma cell lines
Laboratory:
- no Loincs found
Related
Merkel cell carcinoma (neuroendocrine cancer of skin, trabecular cancer)
General
polyomavirus
Properties
KINGDOM: virus
GENOME-TYPE: deoxyribonucleic acid (DNA)
DOUBLE-STRANDED
GENOME-SIZE: 5-9 kB
ENVELOPE: NONE
CAPSID-SYMMETRY: ICOSAHEDRAL
References
- Feng H et al,
Clonal integration of a polyoma virus in human Merkel cell
carcinoma.
Science 2008, Jan 17 ePub
PMID: 18202256
- Touze A et al
High levels of antibodies against Merkel cell
polyomavirus identify a subset of patients with Merkel cell
carcinoma with better clinical outcome.
J Clin Oncol 2011 Apr 20; 29:1612.
PMID: 21422439
- Paulson KG et al.
Transcriptome-wide studies of Merkel cell carcinoma and
validation of intratumoral CD8+ lymphocyte invasion as an
independent predictor of survival.
J Clin Oncol 2011 Apr 20; 29:1539.
PMID: 21422430