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menin-associated histone methyltransferase complex
Function:
- KMT2B/MLL4 in the complex methylates Lys-4 of histone H3
- H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation
- interacts with POLR2A & POLR2B via MEN1
Structure:
- subunits include: KMT2B/MLL4, ASH2L, RBBP5, WDR5, DPY30, MEN1
General
histone methyltransferase (HMT) complex; SET1 complex
Properties
COMPARTMENT: cell nucleus
MOTIF: active site
SUBUNITS: NIL
References
UniProt :accession Q9UMN6