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maternal embryonic leucine zipper kinase; hMELK; protein kinase PK38; hPK38 (MELK, KIAA0175)
Function:
- phosphorylates ZNF622; may contribute to its translocation to the nucleus
- may be involved in the inhibition of spliceosome assembly during mitosis
- autophosphorylated
- Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (probable)
- interacts with ZNF622 & PPP1R8
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
- contains 1 KA1 (kinase-associated) domain
- contains 1 protein kinase domain
Compartment: cytoplasm (putative)
Expression:
- expressed in placenta, kidney, thymus, testis, ovary & intestine
General
serine/threonine kinase
Properties
SIZE: entity length = 651 aa
MW = 75 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 11-263
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 17-25
ATP-binding site
NAME: ATP-binding site
SITE: 40-40
aspartate residue {D132}
Ser phosphorylation site {S335}
Ser phosphorylation site {S356}
Ser phosphorylation site {S431}
Thr phosphorylation site {T446}
Thr phosphorylation site {T460}
Thr phosphorylation site {T478}
Thr phosphorylation site {T494}
Ser phosphorylation site {S498}
Ser phosphorylation site {S505}
Thr phosphorylation site {T518}
Ser phosphorylation site {S529}
KA1 {602-651}
Database Correlations
OMIM 607025
UniProt Q14680
PFAM correlations
Entrez Gene 9833
Kegg hsa:9833
ENZYME 2.7.1.37
References
- OMIM :accession 607025
- UniProt :accession Q14680