Search
melanoma
malignant tumor of melanocytic origin.
Etiology: [1]
1) cutaneous melanoma (85%)
2) other sites (15%)
a) intraocular melanoma (12%)
b) vulva (1%)
c) others (0.1-1%)
- soft tissues, anus, rectum, vagina, mouth [4], GI tract, upper respiratory tract, bronchus* [5] (images)
d) others < 0.1%
- lung, lip, penis, genitourinary, napsopharynx
* melanoma of bronchus probably metastatic from skin despite negative lymph nodes [5]
Immunopathology:
- see melanoma associated antigens (MAGE)
- S100 +
- vimentin +
- HMB45 +
- melan A +
- microphthalmia associated transcription factor (nucleus)
- most non sarcomatoid +
- spindle cell/desmoplastic less positive staining
Laboratory:
- see ARUP consult [2]
Management:
- treatment of melanoma of the bronchus with trametinib & dabrafenib [5]
Interactions
disease interactions
Specific
cutaneous melanoma
intraocular melanoma
General
melanocytic neoplasm
sarcoma
References
- Internal Medicine News: March 1, 2005, pg 23
Terrance O'Grady, Scrips Clinic
- Lange JR, Palis BE, Chang DC, Soong SJ, Balch CM.
Melanoma in children and teenagers: an analysis of patients from
the National Cancer Data Base.
J Clin Oncol. 2007 Apr 10;25(11):1363-8.
PMID: 17416855
- ARUP Consult: Melanoma
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/melanoma
- Song JY
Intraoral Malignant Melanoma
N Engl J Med 2015; 372:1944. May 14, 2015
PMID: 25970052
http://www.nejm.org/doi/full/10.1056/NEJMicm1410451
- Manley C, Olszanski A.
Melanoma in the Bronchus
N Engl J Med 2018; 379:e36. Nov 15, 2018
PMID: 30428282
https://www.nejm.org/doi/full/10.1056/NEJMicm1805380
Images
images related to melanoma