melanoma antigen recognized by T-cells 1 selections

Search

melanoma antigen recognized by T-cells 1; MART-1; melan-A protein; antigen SK29-AA; antigen LB39-AA (MLANA, MART1)

Function: - plays a role in expression, stability, trafficking, & processing of melanocyte protein SILV/PMEL17, involved in formation of stage II melanosomes - interacts with SILV/PMEL17 Structure: - acylated Compartment: - endoplasmic reticulum membrane - single-pass type 3 membrane protein - Golgi, trans-Golgi network membrane - melanosome - also found in small vesicles & tubules dispersed over the entire cytoplasm - a small fraction of the protein is inserted into the membrane in an inverted orientation - inversion of membrane topology results in relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum - melanoma cells expressing MLANA with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing MLANA in its native membrane orientation Expression: - restricted to: - retina - melanoma - melanoma cell lines Laboratory: - Melan-A Ag in tissue Note: see A103 antibody

melan-A Ag in tissue melan-A+Ki67 Ag in tissue

General

melanoma associated antigen (MAGE)

Properties

SIZE: entity length = 118 aa MW = 13 kD COMPARTMENT: cytoplasm golgi endoplasmic reticulum MOTIF: transmembrane domain {27-47}

Database Correlations

OMIM 605513 UniProt Q16655 Entrez Gene 2315 Kegg hsa:2315

References

UniProt :accession Q16655
Dabbs. Diagnostic Immunohistochemistry. Churchill-Livingstone, 2002 p 223.