homeobox protein Meis1 (MEIS1)

Function: - acts as a transcriptional regulator of PAX6 - acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2 - required for hematopoiesis, megakaryocyte lineage development & vascular patterning - may function as a cofactor for HOXA7 & HOXA9 in the induction of myeloid leukemias - interacts with the N-terminal region of PBX1 to form a heterodimer which binds a cAMP-responsive sequence in the CYP17 promoter - also forms heterodimers with PBX2 - forms heterotrimers with PBX1 or PBX2 & a number of HOX proteins including HOXA9, HOXD4 & HOXD9 where it acts as a non-DNA-binding partner - also forms heterotrimers with PBX1 & HOX proteins including HOXD9 & HOXD10 where PBX1 is the non-DNA-binding partner Structure: - belongs to the TALE/MEIS homeobox family - contains 1 homeobox DNA-binding domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: - expressed at low level in normal immunohepatopoietic tissues, including the fetal liver - expressed in a subset of myeloid leukemia cell lines, with highest expression seen in those with a megakaryocytic- erythroid phenotype - also expressed at high levels in the cerebellum Pathology: - defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7

Properties

SIZE: entity length = 390 aa MW = 43 kD COMPARTMENT: cell nucleus MOTIF: threonine-rich region {194-240} MOTIF: threonine residue (SEVERAL) acidic region {242-269} MOTIF: acidic residue (SEVERAL) homeodomain SITE: 272-334 transcriptional activation domain SITE: 335-390

Database Correlations

OMIM correlations UniProt O00470 Pfam PF05920 Entrez Gene 4211 Kegg hsa:4211

References

UniProt :accession O00470