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MADS box transcription enhancer factor 2D; myocyte enhancer factor 2D (MEF2D)
Function:
1) transcription factor
2) binds specifically to the MEF2 element present in regulatory regions of many muscle-specific genes
3) activates transcription via MEF2 element
4) involved in muscle-specific &/or growth factor-related transcription
5) interacts with HDAC4
Structure: heterodimer
Compartment: nucleus
Alternative splicing: named isoforms=6
Expression:
- expressed in muscle cell lineages
- expressed in myotubes & undifferentiated myoblasts
General
MADS box transcription enhancer factor 2; myocyte enhancer factor 2 (MEF2)
phosphoprotein
Properties
SIZE: MW = 56 kD
entity length = 521 aa
COMPARTMENT: cell nucleus
MOTIF: MADS domain or MADS box {3-57}
MOTIF: DNA-binding motif
binding site
FOR-BINDING-OF: transcription factor
lysine-rich region {3-31}
MOTIF: lysine residue (SEVERAL)
DNA-binding motif
SITE: 58-86
Ser phosphorylation site {S212}
proline-rich region
SITE: 252-255
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 365-404
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 451-456
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 600663
UniProt Q14814
Pfam PF00319
Entrez Gene 4209
References
- OMIM :accession 600663
- Entrez Gene :accession 4209
- UniProt :accession Q14814