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MADS box transcription enhancer factor 2C; myocyte enhancer factor 2C (MEF2C)
Function:
1) transcription factor
2) binds specifically to the MEF2 element present in regulatory regions of many muscle-specific genes
3) activates transcription via MEF2 element
4) controls cardiac morphogenesis & myogenesis
5) involved in vascular development
6) neurogenesis & development of cortical architecture (putative)
7) interacts with HDAC7, CARM1, HDAC4
8) Ser-59 phosphorylation enhances DNA binding activity
9) Ser-396 phosphorylation represses transcriptional activity
Compartment: nucleus
Alternative splicing:
- named isoforms=3
- isoforms 3 & 4, which lack the repressor domain, are more active than isoforms 1 & 2
Expression:
- expressed in brain & skeletal muscle
- expression is highest during the early stages of postnatal development
General
MADS box transcription enhancer factor 2; myocyte enhancer factor 2 (MEF2)
phosphoprotein
Properties
SIZE: MW = 51 kD
entity length = 473 aa
COMPARTMENT: cell nucleus
MOTIF: MADS domain or MADS box {3-57}
MOTIF: DNA-binding motif
binding site
FOR-BINDING-OF: transcription factor
lysine-rich region {4-31}
MOTIF: lysine residue (SEVERAL)
DNA-binding motif
SITE: 58-86
MOTIF: Ser phosphorylation site {S59}
serine-rich region {146-183}
MOTIF: serine residue (SEVERAL)
silencer element
SITE: 368-399
MOTIF: Ser phosphorylation site {S396}
Database Correlations
OMIM 600662
UniProt Q06413
Pfam PF00319
Entrez Gene 4208
References
- OMIM :accession 600662
- Entrez Gene :accession 4208
- UniProt :accession Q06413