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MADS box transcription enhancer factor 2B; myocyte enhancer factor 2B (MEF2B)
Function:
1) transcription factor
2) binds specifically to the MEF2 element present in regulatory regions of many muscle-specific genes
3) activates transcription via MEF2 element
4) involved in muscle-specific &/or growth factor-related transcription.
5) interacts with HDAC7
Structure: heterodimer
Compartment: nucleus
Expression:
- expressed in skeletal muscle, cardiac muscle, brain
General
MADS box transcription enhancer factor 2; myocyte enhancer factor 2 (MEF2)
Properties
SIZE: MW = 39 kD
entity length = 365 aa
COMPARTMENT: cell nucleus
MOTIF: MADS domain or MADS box {3-57}
MOTIF: DNA-binding motif
binding site
FOR-BINDING-OF: transcription factor
lysine-rich region {4-31}
MOTIF: lysine residue (SEVERAL)
DNA-binding motif
SITE: 58-86
Database Correlations
OMIM 600661
UniProt Q02080
Pfam PF00319
Entrez Gene 4207
References
- OMIM :accession 600661
- Entrez Gene :accession 4207
- UniProt :accession Q02080