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medullary sponge kidney disease
Pathology:
1) small cystic outpouching of the renal papillary collecting ducts
2) does NOT lead to a decrease in glomerular filtration rate
3) ectactic ducts of Bellini (papillary ducts)
4) nephrocalcinosis
Genetics:
1) autosomal dominant form
2) sporadic form
Clinical manifestations:
1) nephrolithiasis
2) renotubular abnormalities
Laboratory:
1) microscopic or gross hematuria
2) hypercalciuria
3) nephrocalcinosis
Radiology:
1) excretory urography:
a) dilated collecting ducts
b) unilateral, bilateral or involving a single papilla
2) calcifications of collecting ducts may be visualized on plain radiographs
Related
medullary cystic kidney disease
General
renal tubular disease
polycystic kidney disease
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 614
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Harrison's Principles of Internal Medicine, 13th ed.
Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1324