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lactadherin (milk fat globule-EGF factor 8, MFG-E8, HMFG, breast epithelial antigen BA46, MFGM, [Contains: Lactadherin short form; Medin], MFGE8)
Function:
1) specific ligand for the alpha-v/beta-3 & alpha-v/beta-5 receptors
2) also binds to phosphatidylserine-enriched cell surfaces (receptor-independen)
3) binds zona pellucida, role in gamete interaction
Structure:
- medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273
- contains 1 EGF-like domain
- contains 2 F5/8 type C domains
Compartment: membrane, peripheral membrane
Expression:
- expressed on mammary epithelial cell surfaces & in aortic media
Pathology:
- binds specifically to rotavirus & inhibits its replication
- medin is the main constituent of aortic medial amyloid
- overexpressed in several carcinomas
General
glycoprotein
membrane protein
Properties
SIZE: MW = 43 kD
entity length = 387 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
EGF domain {24-67}
MOTIF: cysteine residue {C27}
MODIFICATION: cysteine residue {C38}
cysteine residue {C32}
MODIFICATION: cysteine residue {C55}
cysteine residue {C38}
MODIFICATION: cysteine residue {C27}
Cell attachment {46-48}
cysteine residue {C55}
MODIFICATION: cysteine residue {C32}
cysteine residue {C57}
MODIFICATION: cysteine residue {C66}
cysteine residue {C66}
MODIFICATION: cysteine residue {C57}
coagulation factors 5/8 type C domain (FA58C) {70-225}
MOTIF: cysteine residue {C70}
MODIFICATION: cysteine residue {C225}
cysteine residue {C212}
MODIFICATION: cysteine residue {C216}
cysteine residue {C216}
MODIFICATION: cysteine residue {C212}
cysteine residue {C225}
MODIFICATION: cysteine residue {C70}
coagulation factors 5/8 type C domain (FA58C) {230-387}
MOTIF: cysteine residue {C230}
MODIFICATION: cysteine residue {C387}
N-glycosylation site {N238}
N-glycosylation site {N325}
N-glycosylation site {N329}
N-glycosylation site {N350}
cysteine residue {C387}
MODIFICATION: cysteine residue {C230}
Database Correlations
OMIM 602281
UniProt Q08431
PFAM correlations
References
UniProt :accession Q08431