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meclofenamate (Meclomen)
Tradenames: Meclomen {meclofenamate] & Ponstel {meclofenamic acid}.
Indications:
1) temporary relief of minor aches, pains, fever & inflammation
2) primary dysmenorrhea
- menorrhagia [4]
Dosage:
- 50 mg PO TID/QID, max 300 mg/day {meclofenamate}
- 250 mg PO QID {meclofenamic acid}.
Tabs: 50, 100 mg {meclofenamate} 250 mg {meclofenamic acid}.
Pharmacokinetics:
- duration of action: 2-4 hours
Adverse effects:
1) common (> 10%)
- rash, dizziness, abdominal cramps, heartburn, indigestion, nausea
2) less common (1-10%)
- itching, ringing in ears, fluid retention, headache, nervousness, vomiting
3) uncommon (< 1%)
- congestive heart failure, hypertension, arrhythmia, epistaxis, confusion, hallucinations, aseptic meningitis, depression, peripheral neuropathy, urticaria, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, gastritis, GI ulceration, cystitis, agranulocytosis, anemia, hemolytic anemia, bone marrow suppression, leukopenia, thrombocytopenia, hepatitis, angioedema, allergic rhinitis, toxic amblyopia, blurred vision, conjunctivitis, dry eyes, decreased hearing, polyuria, shortness of breath, olydipsia, tachycardia, hot flashes, drowsiness, insomnia, acute renal failure
Laboratory:
1) specimen: plasma
2) methods: HPLC, GC
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
General
non-steroidal anti-inflammatory agent (NSAID)
Properties
INHIBITS: cyclooxygenase
MISC-INFO: elimination route LIVER
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995
- Deprecated Reference