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A disintegrin & metalloproteinase domain 9; metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase; meltrin gamma (ADAM9, KIAA0021, MCMP, MDC9, MLTNG)
Function:
- probable Zn+2 protease
- may mediate cell-cell or cell-matrix interactions
- isoform 2 displays alpha-secretase activity for APP
- interacts with MAD2L2
- cytoplasmic domain interacts with SH3 domain of endophilin 1 & protein kinase C
Cofactor: binds 1 Zn+2 per subunit (probable)
Structure:
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- expressed in chondrocytes
- highest expression of isoform 2 found in liver & heart
Note: has sometimes been referred to as ADAM-12
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 819 aa
MW = 91 kD
MOTIF: signal sequence {1-28}
N-glycosylation site {N125}
N-glycosylation site {N144}
N-glycosylation site {N154}
Peptidase M12B {212-406}
MOTIF: N-glycosylation site {N231}
cysteine residue {C322}
MODIFICATION: cysteine residue {C401}
Zn+2-binding site
SITE: 347-347
glutamate residue {E348}
Zn+2-binding site
SITE: 351-351
Zn+2-binding site
SITE: 357-357
cysteine residue {C363}
MODIFICATION: cysteine residue {C385}
cysteine residue {C365}
MODIFICATION: cysteine residue {C370}
cysteine residue {C370}
MODIFICATION: cysteine residue {C365}
N-glycosylation site {N381}
cysteine residue {C385}
MODIFICATION: cysteine residue {C363}
cysteine residue {C401}
MODIFICATION: cysteine residue {C322}
disintegrin domain {414-501}
MOTIF: cysteine residue {C473}
MODIFICATION: cysteine residue {C493}
N-glycosylation site {N487}
cysteine residue {C493}
MODIFICATION: cysteine residue {C473}
cysteine-rich region {505-634}
EGF domain {644-698}
MOTIF: cysteine residue {C644}
MODIFICATION: cysteine residue {C656}
cysteine residue {C650}
MODIFICATION: cysteine residue {C662}
cysteine residue {C656}
MODIFICATION: cysteine residue {C644}
cysteine residue {C662}
MODIFICATION: cysteine residue {C650}
cysteine residue {C664}
MODIFICATION: cysteine residue {C673}
cysteine residue {C673}
MODIFICATION: cysteine residue {C664}
transmembrane domain {698-718}
Ser phosphorylation site {S758}
Thr phosphorylation site {T761}
proline-rich region
SITE: 790-795
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y815}
Database Correlations
OMIM 602713
UniProt Q13443
PFAM correlations
Entrez Gene 8754
Kegg hsa:8754
References
- OMIM :accession 602713
- Yong VW et al
Metalloproteinases in biology and pathology of the nervous
system.
Nat Rev Neurosci. 2001 Jul;2(7):502-11. Review.
PMID: 11433375
- UniProt :accession Q13443