Search
DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21 (MCM4 CDC21)
Function:
- role in the control of DNA replication
- forms a stable trimeric complex with p85MCM & p105MCM
- protein BM28/Mcm2 is more loosely associate with the trimeric complex
Structure:
- belongs to the MCM family
- contains 1 MCM domain
Compartment:
- nucleus (putative)
General
minichromosome maintenance (Mcm) protein
phosphoprotein
Properties
SIZE: entity length = 863 aa
MW = 97 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T19}
Ser phosphorylation site {S26}
Ser phosphorylation site {S31}
Ser phosphorylation site {S32}
Ser phosphorylation site {S34}
Ser phosphorylation site {S54}
Thr phosphorylation site {T102}
Ser phosphorylation site {S105}
Thr phosphorylation site {T110}
Ser phosphorylation site {S120}
Ser phosphorylation site {S131}
Ser phosphorylation site {S142}
Ser phosphorylation site {S145}
Ser phosphorylation site {S326}
MCM {458-667}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 510-517
Database Correlations
OMIM 602638
UniProt P33991
Pfam PF00493
Entrez Gene 4173
Kegg hsa:4173
References
- UniProt :accession P33991
- Musahl C et al
A human homologue of the yeast replication protein Cdc21.
Interactions with other Mcm proteins.
Eur J Biochem 230:1096 1995
PMID: 7601140
- NIEHS-SNPs
http://egp.gs.washington.edu/data/mcm4/
Component-of
minichromosome maintenance (Mcm) complex