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DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; RLF subunit beta; P102 protein; P1-MCM3 (MCM3)
Function:
- acts as a factor that allows the DNA to undergo a single round of replication per cell cycle
- required for DNA replication & cell proliferation
- phosphorylated upon DNA damage, probably by ATM or ATR
- gene is activated during S-phase & P1 is phosphorylated
Structure:
- human P1 protein is a homolog of the yeast Mcm3 (minichromosome maintenance protein)
- belongs to the MCM family
- contains 1 MCM domain
Compartment:
- nucleus
- associated with the replication-specific DNA polymerase alpha
- P1 remains in the nucleus during & after S-phase in contrast to yeast Mcm3
General
minichromosome maintenance (Mcm) protein
phosphoprotein
Properties
SIZE: entity length = 808 aa
MW = 91 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S160}
MCM {295-502}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 345-352
Ser phosphorylation site {S535}
Ser phosphorylation site {S668}
Ser phosphorylation site {S672}
Thr phosphorylation site {T674}
Ser phosphorylation site {S681}
Ser phosphorylation site {S704}
Tyr phosphorylation site {Y708}
Ser phosphorylation site {S711}
Thr phosphorylation site {T713}
Thr phosphorylation site {T722}
Thr phosphorylation site {T725}
Ser phosphorylation site {S728}
Ser phosphorylation site {S734}
Database Correlations
OMIM 602693
UniProt P25205
Pfam PF00493
Entrez Gene 4172
Kegg hsa:4172
References
- Schulte D et al
Expression, phosphorylation and nuclear localization of the
human P1 protein, a homologue of the yeast Mcm 3 replication
protein.
J Cell Science 108:1381 1995
PMID: 7615659
- Burkhart R et al
Interactions of human nuclear proteins P1Mcm3 and P1Cdc46.
PMID: 7705359
Eur J Biochem 228:431 1995
- UniProt :accession P25205
- NIEHS-SNPs
http://egp.gs.washington.edu/data/mcm3/
Component-of
minichromosome maintenance (Mcm) complex