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mutated in colon cancer [MCC] anti-oncoprotein; colorectal mutant cancer protein; protein MCC (MCC)
Function:
- candidate for the putative colorectal tumor suppressor gene located at 5q21
- postulated to bind to heterotrimeric Gq-protein inhibiting its interaction with receptor-catalyzed GDP/GTP exchange
Structure: belongs to the MCC family
Expression: expressed in a variety of tissues
Pathology:
- probably involved in early stages of colorectal carcinoma in both sporadic & familial tumors
Related
Mutated in Colon Carcinoma [MCC] tumor suppressor gene
General
anti-oncoprotein (tumor suppressor protein)
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: entity length = 829 aa
MW = 93 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {CC1}
hinge region {HR1}
binding site
FOR-BINDING-OF: Gq-protein
coiled coil {CC2}
hinge region {HR2}
coiled coil {CC3}
hinge region {HR3}
coiled coil {CC4}
hinge region {HR4}
coiled coil {CC5}
Database Correlations
OMIM 159350
UniProt P23508
Pfam PF10506
Entrez Gene 4163
References
- UniProt :accession P23508
- Bourne HR.
Colon cancer. Consider the coiled coil....
Nature. 1991 May 16;351(6323):188-90.
PMID: 1645848