Search
muscleblind-like X-linked protein (muscleblind-like protein 3, Cys3His CCG1-required protein, protein HCHCR, MBNL3, CHCR, MBLX39, MBXL)
Function:
- inhibits terminal muscle differentiation, acting at approximately the time of myogenin induction (putative)
Structure: contains 4 C3H1-type zinc fingers
Compartment:
- nucleus, cytoplasm
- greater concentration in nucleus
Alternative splicing: named isoforms=4
Expression: highly expressed in the placenta
Pathology:
- in myotonic dystrophy (1 & 2) colocalizes with nuclear foci of retained expanded-repeat transcripts
General
zinc finger protein
Properties
SIZE: MW = 39 kD
entity length = 354 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 18-39
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 52-71
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 118-169
MOTIF: proline residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 178-199
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 214-233
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 300413
UniProt Q9NUK0
Pfam PF00642
References
UniProt :accession Q9NUK0