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mannose-binding protein C; MBP-C; MBP1; mannan-binding protein; mannose-binding lectin (MBL2, MBL)
Function:
- role in host defense against pathogens, by activating the classical complement pathway independently of antibody (via mannose-binding lectin pathway)
- binds mannose & N-acetylglucosamine (Ca+2-dependent) expressed on the surface of certain pathogens
- reported to react with acapsular gram-positive & gram-negative bacteria, mycobacteria, viruses, yeast, parasites & protozoa
- upon recognition of antigen, MBL2 adopts a conformational change that leads to activation of serine proteases MASP1 & MASP2 [4]
- interacts with MASP1 & MASP2 (Ca+2-dependent)
Structure:
- oligomeric complex of 6 set of homotrimers
- contains 1 C-type lectin domain
- contains 1 collagen-like domain
Expression:
- formed in the liver
- present in plasma at about 1.5 ug/mL [4]
Pathology:
- there is an association between low levels of MBL2 & a defect of opsonization which results in susceptibility to frequent & chronic infections
- genetic variations in MBL2 are associated with susceptibility to hepatitis B virus infection
Comparative biology:
- found in all mammals
Related
mannan-binding lectin pathway (MLB pathway)
mannose binding lectin (GO:0005532)
General
Ca+2 binding protein
collectin
Properties
SIZE: entity length = 248 aa
MW = 26 kD
MOTIF: signal sequence {1-20}
cysteine-rich region {21-41}
Collagen-like {42-99}
Ca+2-binding site
C-type lectin {134-245}
MOTIF: cysteine residue {C155}
MODIFICATION: cysteine residue {C244}
cysteine residue {C222}
MODIFICATION: cysteine residue {C236}
cysteine residue {C236}
MODIFICATION: cysteine residue {C222}
cysteine residue {C244}
MODIFICATION: cysteine residue {C155}
Database Correlations
OMIM correlations
UniProt P11226
PFAM correlations
Entrez Gene 4153
Kegg hsa:4153
References
- UniProt :accession P11226
- GeneReviews
http://www.genetests.org/query?gene=MBL2
- Functional glycomics gateway - glycan binding
Note: mannose-binding protein
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_227
- Henry's Clinical Diagnosis & Management by Laboratory Methods,
21st edition, McPherson RA & Pincus MR (es), W.B. Saunders Co.,
Philadelphia, PA. 2007