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methyl-CpG-binding domain protein 3; methyl-CpG-binding protein MBD3 (MBD3)
Function:
- does not bind DNA by itself
- recruits histone deacetylases & DNA methyltransferases
- acts as transcriptional repressor & plays a role in gene silencing
- heterodimer with MBD2
- part of the NuRD complex & the MeCP1 complex
- binds HDAC1, MTA2, DNMT1, p66-alpha & p66-beta
Structure: contains 1 MBD (methyl-CpG-binding) domain
Compartment:
- nucleus
- nuclear, in discrete foci
Alternative splicing: named isoforms=2
Related
DNA methylation (promoter methylation)
General
methyl-CpG-binding protein (MECP, Me-CpG-BP)
phosphoprotein
Properties
SIZE: entity length = 291 aa
MW = 33 kD
COMPARTMENT: cell nucleus
MOTIF: MBD {1-72}
MOTIF: Ser phosphorylation site {S56}
coiled coil {216-245}
glutamate-rich region {272-281}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 603573
UniProt O95983
Pfam PF01429
Entrez Gene 53615
Kegg hsa:53615
References
- OMIM :accession 603573
- UniProt :accession O95983
Component-of
nucleosome remodeling & histone deacetylation (NuRD) complex