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dexamethasone/neomycin/polymixin-B (Maxitrol, Dexasporin)

Indications: - steroid responsive inflammatory ocular conditions with risk of bacterial infection Contraindications: pregnancy-category C safety in lactation ? Dosage: Ophthalmic agent: - ointment: BID-QID - solution: 1 drop every 1-6 hours Ointment: (ophthalmic) - neomycin sulfate 0.35%, polymixin B sulfate 10,000 units & dexamethasone 0.1%/ g (3.5 g) Suspension: (ophthalmic) - neomycin sulfate 0.35%, polymixin B sulfate 10,000 units & dexamethasone 0.1%/ mL (5 mL) Adverse effects: - not common (1-10%) - cutaneous sensitization, pain, cataracts, development of glaucoma, increased intraocular pressure, optic nerve damage, contact dermatitis, delayed wound healing

General

antibiotic-glucocorticoid combination

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

dexamethasone (Decadron, Maxidex, AK-Dex, Ozurdex) neomycin (Mycifradin) polymixin B (Aerosporin)