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MATCH study

Aspirin* & clopidogrel in combination is NOT superior to clopidogrel alone in secondary prevention of ischemic stroke or transient ischemic attack, but is associated with an increased risk of serious bleeding, including intracranial hemorrhage. * 81 mg of aspirin QD

General

clinical trial

References

  1. Journal Watch 24(17):133, 2004 Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ; MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo- controlled trial. Lancet. 2004 Jul 24;364(9431):331-7. PMID: 15276392
  2. Prescriber's Letter 11(10): 2004 Concomitant use of Aspirin and Clopidogrel (Plavix) in Cerebrovascular Disease Detail-Document#: 201002 (subscription needed) http://www.prescribersletter.com