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mastectomy

Excision (removal) or the breast Indications: - treatment of breast cancer - prophylactic contralateral mastectomy - BRCA1/BRCA2 genotyping positive - *a genetic mutation of BRCA1 or BRCA2 or another known mutation - a strong family history of breast cancer - *at least 2 first-degree relatives with breast cancer or ovarian cancer with no demonstrable mutations Management: - breast reconstruction after mastectomy facilitated by the use of breast implants [3] - some reconstruction techniques use autologous tissue [3] - nipple-sparing mastectomy with similar overall & disease-free survival to total mastectomy [8] Notes: - young women with unilateral breast cancer who elect for prophylactic bilateral mastectomy overestimate risk [2] - increasing despite lack of survival benefit or prevention of metastatic recurrence [6] - 31% of women who elect contralateral prophylactic mastectomy have a clinical indication for the procedure [4] - women with early-stage breast cancer who are eligible for breast conservation surgery are increasingly opting for mastectomy [5]

Specific

mastectomy for gynecomastia radiation therapy after mastectomy radical mastectomy

General

general surgery surgical resection (excision)

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  2. Rosenberg SM et al Perceptions, Knowledge, and Satisfaction With Contralateral Prophylactic Mastectomy Among Young Women With Breast Cancer: A Cross-sectional Survey Ann Intern Med. 2013;159(6):373-381 PMID: 24042365 http://annals.org/article.aspx?articleid=1738492 - Portschy PR and Tuttle TM Contralateral Prophylactic Mastectomy: Perceptions Versus Reality. Ann Intern Med. 2013;159(6):428-429 PMID: 24042370 http://annals.org/article.aspx?articleid=1738497
  3. Jagsi R et al. Trends and variation in use of breast reconstruction in patients with breast cancer undergoing mastectomy in the United States. J Clin Oncol 2014 Feb 18 PMID: 24550418 http://jco.ascopubs.org/content/early/2014/02/18/JCO.2013.52.2284
  4. Hawley ST et al Social and Clinical Determinants of Contralateral Prophylactic Mastectomy. JAMA Surg. Published online May 21, 2014 PMID: 24849045 http://archsurg.jamanetwork.com/article.aspx?articleid=1873911
  5. Kummerow KL et al Nationwide Trends in Mastectomy for Early-Stage Breast Cancer. JAMA Surg. Published online November 19, 2014 PMID: 25408966 http://archsurg.jamanetwork.com/article.aspx?articleid=1921808 - Sun B, Zenilman ME The Swinging Pendulum. JAMA Surg. Published online November 19, 2014 PMID: 25409114 http://archsurg.jamanetwork.com/article.aspx?articleid=1921805
  6. Jagsi R, Hawley ST, Griffith KA et al. Contralateral prophylactic mastectomy decisions in a population- based sample of patients with early-stage breast cancer. JAMA Surg 2017 Mar 1; 152:274 PMID: 28002555 http://jamanetwork.com/journals/jamasurgery/article-abstract/2593807 - Katz SJ, Janz NK, Abrahamse P et al Patient Reactions to Surgeon Recommendations About Contralateral Prophylactic Mastectomy for Treatment of Breast Cancer. JAMA Surg. 2017 Apr 5. PMID: 28384687
  7. Ramaswami R, Morrow M, Jagsi R. Contralateral Prophylactic Mastectomy. N Engl J Med 2017; 377:1288-1291. September 28, 2017 PMID: 28953446 http://www.nejm.org/doi/full/10.1056/NEJMclde1708293
  8. Coffey S Large Analysis Confirms Safety of Nipple-Sparing Mastectomy. Medscape, December 02, 2021 https://www.medscape.com/viewarticle/964017 - Fu M, Chen Q, Zwng L et al Prognosis Comparison Between Nipple-Sparing Mastectomy and Total Mastectomy in Breast Cancer: A Case-Control Study After Propensity Score Matching. Ann Surg Oncol 2021. Nov 20 PMID: 34802105 https://link.springer.com/article/10.1245/s10434-021-11044-4