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Mas-related G protein-coupled receptor member X2 (MRGPRX2, MRGX2)
Function:
1) cortistatin-14 seems to be a high potency ligand
2) nociceptor function &/or development
- sensation or modulation of pain
3) ortistatin-14 may be ligand
4) Gq protein-coupled receptor (putative)
Structure:
- belongs to the G-protein coupled receptor 1 family mas subfamily
Compartment: cell membrane
Expression:
- limited expression profile
a) expressed in CNS & peripheral nervous system
b) highest in dorsal root ganglion
General
mas-related G protein coupled receptor
Properties
SIZE: MW = 37 kD
entity length = 330 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-33}
transmembrane domain {34-54}
cytoplasmic loop {55-63}
transmembrane domain {64-84}
exoplasmic loop {85-96}
transmembrane domain {97-117}
cytoplasmic loop {118-144}
transmembrane domain {145-165}
exoplasmic loop {166-184}
transmembrane domain {185-205}
cytoplasmic loop {206-228}
transmembrane domain {229-249}
exoplasmic loop {250-264}
transmembrane domain {265-285}
cytoplasmic domain {286-330}
Database Correlations
OMIM 607228
UniProt Q96LB1
Pfam PF00001
Kegg hsa:1171
References
UniProt :accession Q96LB1