MARVEL domain-containing protein 2 (tricellulin, MARVELD2, TRIC)

Function: - role in the formation of the epithelial barrier - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 1 MARVEL domain Compartment: - membrane - found at tricellular contacts Alternative splicing: named isoforms=2 Pathology: - defects in MARVELD2 are the cause of autosomal recessive congenital sensorineural deafness type 49

General

phosphoprotein transmembrane 6 protein

Properties

SIZE: MW = 64 kD entity length = 558 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-194} MOTIF: Tyr phosphorylation site {Y23} proline-rich region SITE: 45-52 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S116} Ser phosphorylation site {S120} Tyr phosphorylation site {Y159} Thr phosphorylation site {T166} transmembrane domain {195-215} exoplasmic loop {216-223} transmembrane domain {224-244} cytoplasmic loop {245-254} transmembrane domain {255-275} exoplasmic loop {276-291} transmembrane domain {292-312} cytoplasmic loop {313-319} transmembrane domain {320-337} exoplasmic loop {338-341} transmembrane domain {342-362} cytoplasmic domain {363-558} MOTIF: coiled coil {466-490} lysine-rich region {514-517} MOTIF: lysine residue (SEVERAL) coiled coil {524-548}

Database Correlations

UniProt Q8N4S9 PFAM correlations

References

UniProt :accession Q8N4S9