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MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1 (MARK4, KIAA1860, MARKL1)
Function:
- activated by phosphorylation on Thr-214
- ubiquitinated with Lys-29- & Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation
- deubiquitinated by USP9X
- phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
- contains 1 KA1 (kinase-associated) domain
- contains 1 protein kinase domain
- contains 1 UBA domain
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- isoform 2 is brain-specific
General
MAP/microtubule affinity-regulating kinase
Properties
SIZE: entity length = 752 aa
MW = 83 kD
STATE: active state
MOTIF: Ser phosphorylation site {S2}
Thr phosphorylation site {T17}
Ser phosphorylation site {S23}
Ser phosphorylation site {S26}
kinase domain
SITE: 59-310
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 65-73
ATP-binding site
NAME: ATP-binding site
SITE: 88-88
aspartate residue {D181}
Thr phosphorylation site {T214}
UBA domain {324-368}
Ser phosphorylation site {S423}
Ser phosphorylation site {S438}
Ser phosphorylation site {S545}
KA1 {703-752}
Database Correlations
OMIM 606495
UniProt Q96L34
PFAM correlations
Entrez Gene 57787
Kegg hsa:57787
ENZYME 2.7.11.1
References
- UniProt :accession Q96L34
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/MARK4ID419.html