MAP/microtubule affinity-regulating kinase 3; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; protein kinase STK10; Ser/Thr protein kinase PAR-1; par-1a; serine/threonine protein kinase p78 (MARK3, CTAK1, EMK2)

Function: - role in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 & MAP4. - phosphorylates CDC25C on Ser-216 regulates localization & activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 & 14-3-3 & export from the nucleus - activated by phosphorylation on Thr-211 - inhibited by phosphorylation on Thr-564 - phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39 - phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity Structure: - belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily - contains 1 KA1 (kinase-associated) domain - contains 1 protein kinase domain - contains 1 UBA domain Compartment: cell membrane; peripheral membrane protein Alternative splicing: named isoforms=6 Expression: ubiquitous

Properties

SIZE: entity length = 753 aa MW = 84 kD STATE: active state MOTIF: Ser phosphorylation site {S2} Thr phosphorylation site {T3} Ser phosphorylation site {S42} kinase domain SITE: 56-307 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 62-70 Thr phosphorylation site {T61} ATP-binding site NAME: ATP-binding site SITE: 85-85 aspartate residue {D178} Thr phosphorylation site {T211} UBA domain {326-365} MOTIF: Tyr phosphorylation site {Y340} Ser phosphorylation site {S341} Ser phosphorylation site {S374} Ser phosphorylation site {S376} Ser phosphorylation site {S377} Ser phosphorylation site {S378} Ser phosphorylation site {S379} Ser phosphorylation site {S380} Ser phosphorylation site {S383} Thr phosphorylation site {T397} Ser phosphorylation site {S400} Tyr phosphorylation site {Y418} Ser phosphorylation site {S419} Ser phosphorylation site {S436} Thr phosphorylation site {T438} Ser phosphorylation site {S455} Ser phosphorylation site {S456} Ser phosphorylation site {S469} Ser phosphorylation site {S476} Ser phosphorylation site {S494} Ser phosphorylation site {S499} Thr phosphorylation site {T536} Ser phosphorylation site {S540} Thr phosphorylation site {T541} Ser phosphorylation site {S543} Ser phosphorylation site {S545} Thr phosphorylation site {T549} Thr phosphorylation site {T564} Ser phosphorylation site {S583} Ser phosphorylation site {S585} Ser phosphorylation site {S587} Thr phosphorylation site {T591} Ser phosphorylation site {S598} Ser phosphorylation site {S601} Ser phosphorylation site {S639} Ser phosphorylation site {S643} KA1 {704-753}

Database Correlations

OMIM 602678 UniProt P27448 PFAM correlations Entrez Gene 4140 Kegg hsa:4140 ENZYME 2.7.11.1

References

UniProt :accession P27448