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maralixibat; lopixibat (Livmarli)
Indications:
- treatment of cholestatic pruritus in patients with Alagille syndrome >= 1 year
Dosage:
- 380 ug/kg once daily, taken 30 minutes before 1st meal of day
- starting dose: 190 ug/kg orally once daily
- increase to 380 ug/kg once daily after one week, as tolerated
Oral solution: 9.5 mg of maralixibat per mL.
Adverse effects:
- most common (> 5%)
- diarrhea, abdominal pain, vomiting, fat-soluble vitamin deficiency, liver function test abnormalities, gastrointestinal bleeding, bone fractures
Laboratory:
- baseline & periodic liver function tests
Mechanism of action:
- ileal bile acid transporter (IBAT) inhibitor
General
enzyme inhibitor
gastrointestinal agent
Database Correlations
PUBCHEM correlations
References
- Medscape: maralixibat (Rx)
https://reference.medscape.com/drug/livmarli-maralixibat-4000208
- Highlights of preascribing information
maralixibat (Livmarli)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214662s000lbl.pdf