Search
microtubule-associated protein RP/EB family member 3; end-binding protein 3; EB3; EB1 protein family member 3 (EBF3, RP3, MAPRE3)
Function:
1) microtubule polymerization & spindle function by stabilizing microtubules & anchoring them at centrosomes
2) role in cell migration (putative)
3) interacts with DCTN1
4) binds to the C-terminal domain of APC
5) binds monomeric & polymerized tubulin
6) two functionally independent domains
a) N-terminal domain forms an hydrophobic cleft involved in microtubule binding
b) C-terminal involved in formation of mutually exclusive complexes with APC & DCTN1
Structure:
1) belongs to the MAPRE family
2) contains 1 CH domain (calponin-homology domain)
- contains 1 EB1 C-terminal domain
Compartment: cytoplasm, associated with the microtubule network
Alternative splicing: named isoforms=2
Expression: expressed in brain & muscle
General
microtubule-associated protein (MAP)
Properties
SIZE: MW = 32 kD
entity length = 281 aa
COMPARTMENT: cytoplasm
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 14-116
EB1 C-terminal {194-264}
binding site
SITE: 217-281
FOR-BINDING-OF: dynactin-1
MOTIF: binding site
SITE: 217-260
FOR-BINDING-OF: adenomatous polyposis coli protein
Database Correlations
OMIM 605788
UniProt Q9UPY8
PFAM correlations
References
UniProt :accession Q9UPY8