Search
microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1, end-binding protein 1, EB1, MAPRE1)
Function:
1) role in microtubule polymerization & spindle function by stabilizing microtubules & anchoring them at centrosomes
2) role in cell migration (putative)
3) interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 & dynein intermediate chain
4) binds to C-terminal domain of APC
5) interacts with CLASP1 & CLASP2
Structure:
1) homodimer
2) composed of two functionally independent domain
- N-terminal domain forms an hydrophobic cleft involved in microtubule binding
- C-terminal domain is involved in the formation of mutually exclusive complexes with APC & DCTN1
3) belongs to the MAPRE family
4) contains 1 CH domain (calponin-homology domain
- contains 1 EB1 C-terminal domain
Compartment:
- cytoplasm
- associated with microtubule network at the growing distal tip of microtubules.
- also enriched at the centrosome
General
microtubule-associated protein (MAP)
phosphoprotein
Properties
SIZE: MW = 30 kD
entity length = 267 aa
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
calponin homology domain
NAME: calponin homology domain
SITE: 13-115
Tyr phosphorylation site {Y123}
EB1 C-terminal {184-254}
binding site
SITE: 207-267
FOR-BINDING-OF: dynactin-1
MOTIF: binding site
SITE: 219-241
FOR-BINDING-OF: adenomatous polyposis coli protein
Database Correlations
OMIM 603108
UniProt Q15691
PFAM correlations
References
- UniProt :accession Q15691
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/MAPRE1ID455ch20q11.html