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mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; ERK-7; extracellular signal-regulated kinase 8; ERK-8 (MAPK15, ERK7, ERK8)
Function:
1) activated by Thr & Tyr phosphorylation
2) inhibited by dual specificity phosphatases, DUSP1
3) interacts with CSK, ABL1, RET
4) autophosphorylated on Thr, Tyr
5) ubiquitinated by SCF E3 ligase
Structure:
- the N-terminal region (1-20) is the minimal region necessary for ubiquitination & proteasomal degradation
- the TXY motif contains the phospho-Thr site & phospho-Tyr site whose phosphorylation activates MAP kinases
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
- contains 1 protein kinase domain
Alternative splicing: named isoforms=3
Expression:
- widely expressed
- greatest expression in lung, kidney
General
mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase
Properties
SIZE: entity length = 544 aa
MW = 60 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 13-304
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 19-27
ATP-binding site
NAME: ATP-binding site
SITE: 42-42
aspartate residue {D137}
TXY {175-177}
Thr phosphorylation site {T175}
Tyr phosphorylation site {Y177}
Ser phosphorylation site {S392}
Ser phosphorylation site {S415}
Database Correlations
UniProt Q8TD08
Pfam PF00069
Entrez Gene 225689
Kegg hsa:225689
ENZYME 2.7.11.24
References
UniProt :accession Q8TD08