mitogen-activated protein kinase 13 selections

mitogen-activated protein kinase 13; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MAP kinase p38 delta (MAPK13, PRKM13, SAPK4)

Function: - responds to activation by environmental stress & pro-inflammatory cytokines by phosphorylating downstream targets - role in regulation of protein translation by phosphorylating & inactivating EEF2K - activated by phosphorylation on Thr & Tyr by either of two dual specificity kinases, MAP2K3 & MAP2K6 - dually phosphorylated on Thr-180 & Tyr-182, which activates the enzyme Cofactor: Mg⁺² Structure: - TXY motif contains the Thr & Tyr whose phosphorylation activates the MAP kinases - belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily - contains 1 protein kinase domain Expression: - expressed in testes, pancreas, small intestine, lung & kidney - abundant in macrophages - also present in neutrophils, CD4+ T-cells, & endothelial cells

Interactions

molecular events

General

p38MAPK subfamily

Properties

SIZE: entity length = 365 aa MW = 42 kD COMPARTMENT: cytoplasm STATE: active state MOTIF: kinase domain SITE: 25-308 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 31-39 Ser phosphorylation site {S47} ATP-binding site NAME: ATP-binding site SITE: 54-54 aspartate residue {D150} TXY {180-182} Thr phosphorylation site {T180} Tyr phosphorylation site {Y182}

References

Nebreda AR, Porras A. p38 MAP kinases: beyond the stress response. Trends Biochem Sci. 2000 Jun;25(6):257-60. Review. PMID: 10838561
UniProt :accession O15264

Databases & Figures

OMIM 602899 UniProt O15264 Pfam PF00069 Entrez Gene 5603 Kegg hsa:5603 ENZYME 2.7.11.24 MAP kinase pathways