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mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; stress-activated protein kinase 2 (MAPK11, PRKM11, SAPK2)
Function:
- kinase involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
- phosphorylates preferentially transcription factor ATF2
- activated by phosphorylation on Thr & Tyr by MKK6
- inhibited by pyridinyl-imidazole related compounds
- dually phosphorylated on Thr-180 & Tyr-182, which activates the enzyme (probable)
Cofactor: Mg+2 (putative)
Structure:
- TXY motif contains the Thr & Tyr whose phosphorylation activates the MAP kinases
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
- contains 1 protein kinase domain
Expression:
- highest levels in the brain & heart
- also expressed in placenta, lung, liver, skeletal muscle, kidney & pancreas
Interactions
molecular events
General
p38MAPK subfamily
Properties
SIZE: entity length = 364 aa
MW = 41 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 24-308
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 30-38
ATP-binding site
NAME: ATP-binding site
SITE: 53-53
aspartate residue {D150}
TXY {180-182}
Thr phosphorylation site {T180}
Tyr phosphorylation site {Y182}
References
- UniProt :accession Q15759
- NIEHS-SNPs
http://egp.gs.washington.edu/data/mapk11/
Databases & Figures
OMIM 602898
UniProt Q15759
Pfam PF00069
Entrez Gene 5600
Kegg hsa:5600
ENZYME 2.7.11.24
MAP kinase pathways