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microtubule-associated protein 6; MAP-6; Stable tubule-only polypeptide; STOP (MAP6 KIAA1878)
Function:
- role in microtubule stabilization in many celltypes, including neuronal cells
- specifically has microtubule cold stabilizing activity
- interacts with calmodulin (via C-terminus); the interaction is dependent on Ca+2 (putative)
Structure: belongs to the STOP family
Compartment:
- cytoplasm, cytoskeleton, Golgi
-
Alternative splicing: named isoforms=2
Expression:
- expressed in brain (at protein level)
- expressed in spinal cord
Pathology:
- colocalizes with neurofilament (NF)-rich inclusions in neurons in the spinal cord & brain of patients with amyotrophic lateral sclerosis (ALS)
- isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study)
General
microtubule-associated protein (MAP)
phosphoprotein
Properties
SIZE: entity length = 813 aa
MW = 87 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: cysteine residue {C5}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C10}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C11}
MODIFICATION: palmitate
COMPARTMENT: membrane
proline-rich region
SITE: 43-49
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S112}
Mn 1 {118-141}
MOTIF: binding site
SITE: 126-140
FOR-BINDING-OF: calmodulin
Tyr phosphorylation site {Y143}
Mn 2 {153-176}
MOTIF: binding site
SITE: 162-176
FOR-BINDING-OF: calmodulin
binding site
SITE: 189-203
FOR-BINDING-OF: calmodulin
Mn 3 {298-321}
MOTIF: binding site
SITE: 306-320
FOR-BINDING-OF: calmodulin
binding site
SITE: 357-371
FOR-BINDING-OF: calmodulin
binding site
SITE: 384-398
FOR-BINDING-OF: calmodulin
proline-rich region
SITE: 490-804
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S812}
Database Correlations
UniProt Q96JE9
Pfam PF05217
References
UniProt :accession Q96JE9