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mitogen activated protein kinase kinse kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase-1 (MAP4K1, HPK1)

Function: - may play a role in the response to environmental stress - upstream activator of the MEKK/JNK/SAPK signaling pathway - role in hematopoietic lineage decisions & growth regulation (putative) - involved in TGF-beta signaling pathway via TAK1 (MAP3K7) & JNKs - interacts with MAP3K1 ATP + a protein ADP + a phosphoprotein Cofactor: Mg+2 Structure: - belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily - contains 1 CNH domain - contains 1 protein kinase domain Expression: - expressed primarily in hematopoietic organs, including bone marrow, spleen & thymus - also expressed at very low levels in lung, kidney, mammary glands & small intestine

Interactions

molecular events

General

mitogen activated protein kinase kinse kinase kinase

Properties

SIZE: entity length = 833 aa MW = 91 kD STATE: active state MOTIF: kinase domain SITE: 17-274 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 23-31 ATP-binding site NAME: ATP-binding site SITE: 46-46 aspartate residue {D137} Ser phosphorylation site {S366} Ser phosphorylation site {S368} Ser phosphorylation site {S374} Ser phosphorylation site {S376} Tyr phosphorylation site {Y381} Ser phosphorylation site {S407} Ser phosphorylation site {S413} Ser phosphorylation site {S421} CNH {501-807} MOTIF: Ser phosphorylation site {S586}

References

  1. OMIM :accession 601983
  2. Zhou G et al. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. J Biol Chem 274:13133-8, 1999 PMID: 10224067
  3. Sawasdikosol S et al Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription. Blood 101(9):3687-9, 2003 PMID: 12522005
  4. UniProt :accession Q92918

Databases & Figures

OMIM 601983 UniProt Q92918 PFAM correlations Entrez Gene 11184 ENZYME 2.7.11.1 Figures/diagrams/slides/tables related to MEK kinase kinase 1