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mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1 (MAP3K7, TAK1)
Function:
- mediates TGF-beta signal transduction
- component of a protein kinase signal transduction cascade
- mediator of TGF-beta signal transduction
- stimulates NF-kappa-B activation & the p38 MAPK pathway
- binds both upstream activators & downstream substrates in multimolecular complexes
- interacts with MAP3K7IP1 & MAP3K7IP2
- interacts with PPM1L
- association with MAP3K7IP1 promotes autophosphorylation & subsequent activation
ATP + a protein ADP + a phosphoprotein
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
- contains 1 protein kinase domain
Alternative splicing: named isoforms=3
Polymorphism:
- SNPs in intron 1 of MAP3K7 are associated in longevity [2]
Interactions
molecular events
General
mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
Properties
SIZE: entity length = 606 aa
MW = 67 kD
STATE: active state
MOTIF: serine-rich region {8-14}
MOTIF: serine residue (SEVERAL)
kinase domain
SITE: 36-291
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 42-50
ATP-binding site
NAME: ATP-binding site
SITE: 63-63
aspartate residue {D156}
Thr phosphorylation site {T184}
Thr phosphorylation site {T187}
Ser phosphorylation site {S192}
Ser phosphorylation site {S439}
References
- UniProt :accession O43318
- Di Cianni F et al
MAP3K7 and GSTZ1 are associated with human longevity:
a two-stage case-control study using a multilocus genotyping.
Age (Dordr). 2012 May 11
PMID: 22576335
Databases & Figures
OMIM 602614
UniProt O43318
Pfam PF00069
Entrez Gene 6885
ENZYME 2.7.11.25
Figures/diagrams/slides/tables related to MAP kinse kinase kinase 7